Is it mandatory to use DDU in safe mode?

[Deniedstingray]

So whenever i try to wipe GPU drivers it tells me to use safe mode in order to do it safely, However when i do this my mouse and keyboard are unusable because of the drivers the have to run to function. Will using DDU in normal boot mode have any harmful affect on my system?

 

[k1114]

It just won't be able to delete all residual files.