You have the PSU UPSIDE DOWN...the cables should be on the outer side of the case ie...the opposite of the motherboard tray...this misaligns the screw holes and is blocking off two of the screw placements.
The FAN GOES UP, not down...there would be no purpose in blowing the heat down under the psu and then...heat rises naturally...reheating the psu back up in a heat bath which is what happens with the fan facing down...UNLESS...the bottom is vented, but even then...you are still creating a heat bath for the bottom of your case blowing the heat down!
On the two screws being used...if they were catty cornered..opposite sides of the psu...no big deal since it IS on bottom...however with both screws on the left side looking at the back...it runs a chance of the psu coming loose and bending into the motherboard...This Is Not Likely but still a slight chance...I would turn the pwr supply back over putting the power plug on the right side looking at the back of the case and deal with the wiring to get the other two holes to line up and remove any possibility of the psu shifting during a move...taking the pc to be fixed, taking the pc to a lan party, or just moving it around in the location you use it in!
Best practices are labeled that for a reason...best practices prevent possibility of damage through inappropriately secured hardware coming loose or some other calamity that could've been avoided.
Just to be fully truthful...I usually mount my psu's upside down like yours... to enable full reach of the 4,6,8, pin cable for power to cpu... to reach in Full Towers or Supertowers using cutouts and routing through back of case...however I only use PCPower&Cooling PSU's with the fan exhausting out the back of my rig and all my rigs have had alternative mounting for PSU's in the slots to allow for ALL (4) mounting screws to be utilized. I would never put the fan on a PSU DOWN in the bottom of a case...the heat bath thus created would increase possibility of failure due to increased temps to components inside my case, from the naturally rising heat. Psu's Can get HOT!