There are differences.
The main difference is the first two slots will take a SATA SSD and the third one won't.
M2_1 supports up to PCIe 3.0 x4 and SATA 6Gb/s, 2242/ 2260/ 2280/ 22110 storage devices
M2_2 supports up to PCIe 3.0 x4 and SATA 6Gb/s, 2242/ 2260/ 2280 storage devices
M2_3 supports up to PCIe 3.0 x4, 2242/ 2260/ 2280 storage devices