The simple answer is yes. The 1600MHz memory will run at 267MHz faster than the 1333MHz memory, however, that's not always the case. There are bound to be some very high end 1333MHz memory that will run faster than 1600MHz memory or more stable. The speed difference will not be very noticable when running windows, however, in games, the higher speed memory will increase your framerates, albeit by VERY little.