Dust is one of them .... I mean you **can** buy filters and mount them yaslef if ya wanna make an exhaust mount into an intake mount. On way to tell what the manufacturer intended is this... if it has an air filter, then it's an intake.
As for the air around the GPU thing think about what is happening here.... your GFX card fans are taking air from under you card and pushing it up over the heat sink
Look here, we do that test here using a fog machine when setting up case cooling. Skip to the 1 minute mark if you are impatient. As you can seem the general movement is to the back and up, though you can see a mistake there if ya paid attention ... 4 in / 4 out ... negative case pressure.
I blame the video director ! But if ya look at the case, the fact that they provide an intake filter tells ya that its designed for intake ... as it must be if you put a 360 or 420mm rad in there.
That case is really designed for water cooling and
https://www.youtube.com/watch?v=ly9ioBk2tSs
so 1 out and 5 (or 6 in)... that's just fine. Your out is the big giant grille on the back of the case.
I'm not sure, w/o a fog test if you are really really exhausting hot GPU air ... you may be stealing the intake air. Cool air coming in the front would normally get sucked right up thru the GPU and out the rear grille above it. Every case is a lil bit different but as you are ... what is happening is that hot PSU exhaust and hot GFX card exhaust thru the slots come sup an inch or so above the GFX card and negative pressure is sucking the hot air back inside the case.
The 140mm ones will be silent up to about 850 repm ... I mean dead silent, not just low noise. I have 15 of them in my case ... 6 on top rad / 4 on bottom rad (all intakes ofc) and 6 case fans (5 in 1 out). Sometimes i sit down in the morning and turn the PC on... but its already one, you just can't hear it. At low demand, I have the fans set to turn off of the fan curve says we don't need more than 350 rpm ... but even at 850, running stress tests , it's dead silent. Lotta fans at lower speeds.
The Thermalright Silver Arrow is in my son's rig ... for 6 years with a 4.8 Ghz OC on 2600k. It's silent.
You can see the top 22 or so fans in the chart here:
http://www.silentpcreview.com/article1345-page7.html
about half way down the page there's a chart