if that's all your case can fit, then you don't have much alternative.
if your system is for very basic use and/or just doesn't generate much heat then most wouldn't require anything more.
for a modern gaming or highly intensive processing system then that would normally not be enough to bring in sufficient cool air or exhaust sufficient heated air.
depends on where the fans may be placed in relation to other components,
where the system may be located in your living area,
the ambient temperature around the system.
a lot depends on the specific case you will be using and how well air flows through it plus the CPU cooler and how much air filters through it's fins.