ITX boards with 4 RAM slots?

[caibacooper94]

I recall reading a review of an ASRock ITX board with 4 RAM slots, accomplished by using SO-DIMMs:

https://www.asrock.com/mb/Intel/X299E-ITXac/

For me, the only major limitation of the ITX form factor is that it's (almost) universally limited to 2 sticks of RAM. I haven't felt the need for a decade to put anything in a PCIe slot other than a single GPU, but I often want to add more RAM before I'm done with a platform.
Any thoughts on why we don't see more boards doing this?

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[kanewolf]

• 
  ■ Because most desktop CPUs are dual channel memory controllers. They are most efficient with two DIMMs (highest clock, tightest timings).
  ■ Mixing RAM is a gamble at best.
  ■ Memory density usually doubles within a DDR generation so you can get twice the RAM in the same number of DIMMs

When it it time for an upgrade, buy two matched DIMMs with double the density. Sell your old RAM.