Do you have a win 10 installer? If not, on another PC, download the
Windows 10 media creation tool and use it to make a win 10 installer on USB - just a boot drive
Booting off USB means it won't use the drivers on the PC but rather default ones on USB. Mouse/kb should work.
Try running system restore
change boot order so USB is first, hdd second
boot from installer
on screen after languages, choose repair this pc, not install.
choose troubleshoot
choose advanced
choose system restore
Pick a date, if you lucky Asus AI Suite created a restore point before it installed.
PC will restart and hopefully USB works again.
Another option is try to get to safe mode but it isn't always an option when booting from USB
boot from installer, on 2nd screen after languages, choose repair this pc, not install
choose troubleshoot
choose advanced
choose start up options
hit the restart button
choose a safe mode (it doesn't matter which) by using number associated with it.
Pc will restart and load safe mode
If you get this far, try uninstalling AI Suite though no guarantees that will fix this. Reddit link below includes an application that will remove AI suite 3 completely.
It appears the USB 3 booster drivers are what stops the USB devices working... i remember those messed with my external hdd
https://www.reddit.com/r/Windows10/comments/76b05l/asus_ai_suite_3_after_update_1709/