How practical is that drive if it doesn't support TRIM?
for normal day to day use it is actually not that big of a deal. The issues crop up if you are running the drive full, or constantly filling and deleting large portions of the drive, but for most people (and even power users like gamers) it is just an issue where you understand that the drive will not perform at top speed as memory is used and needs to be cleared before being rewritten, and that there may be issues down the road where it can die early due to uneven wear and tear. But unless you are really pushing the drive, most people would never know.
I have 2 SSDs in RAID0 (2x 240GB drives), and I ended up upgrading from a z68 to a z77 motherboard for the sake of having RAID support because I did notice some performance degregation over the course of 3-4 months. It was one of those things where it really wasn't a huge deal... but I wanted to be better safe than sorry, and I would prefer to not replace my drives any time soon. Now I have been on z77 for ~6 months, and things have slowed down a little bit compared to the fresh install, but not nearly to the same extent as it did before. Plus I think a lot of it is in my head as I have 2 mid-level drives, and I have since had the opportunity to use some much higher end drives in other systems. So it may just be me holding the drives to a higher standard.