Left-Click not working

[DarthxGeek]

My left-click is not working. I have 2 mice: one is a cheap iHome mouse and the other is a Luom G10 gaming mouse. Yesterday I discovered my left click was not working on the G10, but the right click did work. I also tested the iHome mouse, and had the same results. The funny thing is, if I right click on a window, and it says something like "Close Window" or "Quit Skype," I can left click these options no problem. Any other situation involving the left click is not possible (i.e opening apps, left clicking options on an application). I have had my Luom G10 for about 3 weeks, and my iHome mouse for 3 months, so it would be out of the ordinary if the buttons were worn out. At first I thought this was a USB port issue, so I tried plugging the mice into all these ports. Still the same issue. It should also be noted that I've previously downloaded all the correct drivers, and all the drivers are up-to-date. Next, I opened up my computer and I took everything out of the case, and hit it with compressed air. I also dusted off the I/O shield. I put everything back in the case and I plugged everything in. It booted up with no problem. I have since rebooted the computer 3 times, tested every USB port with a thumb drive, and the thumb drive wasn't detected every time. I still have the exact same issue with the mouse, and I find it very odd that the left click works for options that are accessible with a right-click. Here are my specs:
Dell Optiplex 790 (modified 3 months ago):
Intel Core i5-2400 Quad Core CPU at 3.1 GHz
EVGA GeForce GTX 960 4gb
Western Digital Blue 250gb 7200 RPM HDD (Boot Drive)
Seagate Barracuda 3TB 7200 RPM HDD (I use this to store my games and music, and I bought it 4 days ago)
4gb 1333 MHz DDR3 RAM (2x2gb)
Stock motherboard
WPower 480W PSU
stock fans
Luom G10 mouse
Logitech G610 Orion Mechanical Gaming Keyboard with Cherry MX Reds
19" Dell monitor

 

[Ralston18]

Check the mice settings via Device Manager and also via Windows Settings > Devices > Mouse and touchpad - Additional mouse settings.

My thought is that some application or game may have changed the mouse settings/configuration.

Also take a look at the "Ease of Access" settings - possibly something there but more likely under "Devices".