I'd have no problems dropping a Supermicro/Tyan server board in there and filling the thing up with as many SAS hard drives as I could get my hands on, though I'm past the days of making my desktops as big as they can possibly be - a lower-high-end mATX/ITX system is more than enough if done properly.
I bet this thing isn't going to come cheaply, and tack shipping ontop of that MSRP, too. Interesting case, though... I could see myself buying one if I ever come up with the budget to get that Xeon workstation pulled together for 3D rendering projects.