For 6 weeks, not worth doing anything special really. If your machine is normally on 24/7 then a power cycle will expose any issues. But in general, make sure you have backed up (but you would always have one anyway).. and turn off power at the plug (make sure you BIOs battery is not old.. unless really old it should last 6 weeks easily)
Hope for best when you turn on after your 6 weeks.
Cheers