Update: With windows 11 the only way one can get smooth performance with this kind of gpu's config seems to be to have both gpu's running the same driver, Like I have noted now this is not how it used to be possible on windows 10 or rather exactly like it was on windows 10, but the one difference being that windows 11 overwrites anything the user or administrator has done (I know one can customize that, but that's not the point) to get any and all gpu's running with the latest possible driver and this is where such an attempt to run simultaneous variant of gpu fails to either run smooth or without windows errors.
As a last note I would not recommend trying this, unless Microsoft and say AMD in this case resolves these issues with drivers. It's quite the trouble when windows 11 runs into errors that wrong drivers cause, and I for one would not accept continual use of an operating system in such a state or even if it had encountered such errors and then supposedly recovered or restored itself, because it don't seem like that function is working right either way.