Sure thing. See this guide;
If you are looking for the Windows 11 Clean install tutorial, you can find that here: Windows 11 Clean install tutorial (Click here) Otherwise, welcome to the Windows 10 Clean install tutorial This tutorial is intended to help you, step by step, to perform a clean install of Windows...
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Backup any personal data because a full reinstall means a full wipe of the destination drive. Have an usb stick handy and is of at least 8GB in size. Follow the guide.
Before you do, if you don't have a dvd drive to use the motherboard driver cd, with another usb stick (any size, enough to store the driver), download the lan or wireless driver (which ever you use to connect internet) from the mobo site and put it a side. Just incase Windows doesn't install lan drivers itself and prevent you connecting to the internet.
After Windows has been reinstalled, let Windows updates do it's thing. Then visit motherboard and gpu website and download and install drivers.