As always, go to the spec sheet:
Experience transformative tech with TUF B450M-PLUS GAMING motherboard. Stellar features meet your lofty specifications, elevating everyday usage.
www.asus.com
The WD Blue is a SATA M.2 drive.
That board will accept a SATA M.2 in that M.2 port
AMD Ryzen™ 2nd Generation/ Ryzen™ with Radeon™ Vega Graphics/ Ryzen™ 1st Generation Processors :
1 x M.2 Socket 3, with M key, type 2242/2260/2280/22110 storage devices support (
SATA & PCIE 3.0 x 4 mode)*1
AMD Athlon™ with Radeon™ Vega Graphics Processors :
1 x M.2 Socket 3, with M key, type 2242/2260/2280/22110 storage devices support (
SATA mode)*1