A 4460 should run 1600 and prob/possibly 1866....2133 might be a stretch, the mobo chipset can handle most any DRAM, but the determining factor in fact is the MC (memory controller) of your individual CPU. And i say individual as not all 4460s are exactly the same - you'll find 4460s that are the 'norm' but some are stronger and can run faster DRAM data rates, as also some can OC higher via use of the BCLK than others. The days of the mobo being the determining factor went by the wayside back about 2009 when the MC moved from the mobo chipset to the CPU itself proper