MMO Mouse, how handy are they? hard to use?

Since creating a Monk character I found that they have, oh about 74 abilities that are all semi-handy to use.

My Steelseries WOW mouse is great, right size, enough buttons (till now) and with using the first few number keys I can get all my hotkeys in use without moving my hands at all.

Now I need to map a ton of abilities, since even a DPS Monk has 2-3-4 healing abilities to toss around if needed, as well as a bunch of attacks and cool-downs.

I would like a mouse similar to
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Are those tough to use due to the large # of buttons close to each other? The WOW mouse has 8 buttons that I have mapped out but they are all on different sides, 4 on the thumb, 2 around the scroll wheel, scroll wheel push and there is a pinkie button (for interupts) Simple to remember and use.