In terms of games the x4 980s and a 5960x would probably be best. ... Getting into the workstation/server spectrum, wait until intels new xeon e7 v3 lineup comes out. The highest end ones are suppossed to have 18 physical core (36 logical), support for 1536GB of ECC RAM, 45MB of L3 cache, a suppossed 3.2ghz clock speed, and the kicker... support for a possible octal socket motherboard. Dont know if one will ever come out and I dont think one exists now thats widely available to the general consumer but the support is suppossedly there. So if you can put that together when a compatible board comes out you could have a theoretical 12TB of error correcting RAM and 144 physical cores (288 logical). I dont know if anyone will ever bring this together but if not just get the current dual socket intel boards, toss in as many Nvidia Tesla K80s and as much ECC RAM as you can possibly fit, and then throw in as many huawei es3000s as you have pci lanes and slots left and that will pretty much be the most overkill single solution you can achieve. ... The news on the new HaswellEX cpus im not necessarily positive on. Theyre slated for a Q2 2015 release so we'll soon see I guess. ... This is the best possible configuration a person could put together themselves in my mind. I mean you could always buy some of oracles sparc servers or something along the lines of (I think they were talking about a 96 socket server at some point a while back but I would have to check) but then you wouldnt have the fun of putting it together yourself (in addition to having to sell your kids and home , lol).