Hey, recently did an extremely overkill build with 4 1080TIs, all watercooled in my desktop. Problem is, the motherboard (And windows) will not detect the 4th graphics card. My Motherboard is the MSI Gaming X Titanium z270 motherboard with an i7 7700k. I would like to not have to disassemble the watercooling loop, but it may be unavoidable. Driver installation of any NVidia drivers fails even when from a disk. I saw in the BIOS a 4G setting that allows for more than 4 gpus, and this may matter as I have a PCIE WIFI CARD in as well. that makes for 5 PCIE devices. The wifi card and 3 GPUS work fine, but the 4th isnt detected. I have tried to set the 4G setting on, but my computer wouldn't load into windows so I just CMOS reset. I did adjust a few settings so it could've been a couple things and I will try just the 4G setting later. Thanks! Just wanted some advice from fellow enthusiasts and if anyone has any ideas. MOBO bios is the newest, but its been updated since I got the board. Windows is latest version. The card works and is NOT broken as far as I know. I have in the past had dead PCIE slots on the board. (3rd board) first had audio issues, second had a dead PCIE SLOT. This one I think works fine as I have had the wireless card in the slot of the card that I think is not working.