Mouse and keyboard don't work

[Brock82]

I am having problems with me Mouse and key board, on boot up they will turn on for about 20 seconds then turn off. Then a error comes up, inaccessible_boot_drive. But if I restart my pc the mouse and keyboard will do the same thing but instead of the error I get, choose keyboard layout, and a list of options but I cant choose them because the mouse isn't working. This all started happening after I upgraded my power supple but I when I put my old power supple in I had the same problem. I have windows 10and I have tried using different keyboards and different usb ports.
Any help is appreciated.

 

[Lutfij]

Have you tried performing these steps? Likewise you can also try and follow up on the suggestions made on this thread.

The other options are:
sfc / scannow
restore point
clean install of Windows 10

Hope these help.