I recently got a 1440p monitor, and I'd agree that you don't really need to go beyond 2x MSAA at that resolution. You can certainly try it if you want, but the performance hit would be rather large for the gains that you would get. Honestly, at that resolution you probably wouldn't be able to notice the difference between 2x and 4x MSAA unless you were very closely scrutinizing a still image. That isn't really worth taking a big performance hit unless you have a monster GPU setup that has plenty of headroom to spare at 1440p.