So yeah you want to shoot for 60FPS settings and vsync. Are you running FRAPS? If no get that now. Monitor your frame rate as you turn up the game's settings graphics settings. When you get close but don't go under 60FPS...turn vsync on your system will lock it at 60FPS/hz. So neither CPU or GPU work to hard. As also stated you can turn up filtering and AA to bring down the frame rate while increasing image quality (ie crisp textures and no jagged edges on objects) something like 16x by 8x or 8x by 4x depending on what your GPU can handle. You may need to set them manually in nvidia control panel or AMD crimson control center depending on which GPU you run.
http://www.fraps.com/