Update your post to include full system hardware specs and OS information.
Include PSU: make, model, wattage, age, condition (original, new, refurbished, used).
Disk drive(s): make, model, capacity, how full?
Try using Task Manager and Resource Monitor (just one or the other at a time) to observe system performance differences between full screen and "smaller" screen.
My first thought being that the PSU is no longer able to support the power demands of the system and/or GPU.
Key is to prove or eliminate that thought.