There's actually an interesting article Tom's Hardware published awhile back that touched on this issue (http://www.tomshardware.com/reviews/graphics-performance-myths-debunked,3739-3.html) - assuming it's PCIe 2.0 or higher, the performance hit shouldn't be enough to seriously harm graphics performance (given the math, at least), though I suppose it is possible. Why do you have it plugged into a 4x slot, anyway?