has to be the same on just about every level other than the PCB maker, but even then you still want it to be from the same board partner. so SLI with two MSI lightnings is a good idea, a Lightning and a Gigabyte card? not so much. pretty much beside the cards having to be the same (So no 1GB and two GB card SLI.) the less differences the better. SLI is already a delicate art, the less factors to deal with the better.