Sorry, but disagree.
Unless this is an unusual motherboard, most motherboards slots 1 & 3 are used for one dual channel, and slots 2 & 4 used for the other dual channel.
My understanding is that Flex mode looks at the two DIMM's inserted in the dual channel slots. Now for dual channel operation, the DIMM memory capacities have to be the same (regardless of Flex mode or anything else). The system sees 4 GB in slot 1, say, and sees 2 GB in slot 3 (slots 1 & 3 being one of the dual channels). If Flex mode is available, then provided the chip architectures, voltages, (and to a lesser extent the speeds and timings) are similar, then the system will use 2 GB of the 4 GB DIMM in dual channel configuration with the 2 GB DIMM. Again, the remaining 2 GB from the 4 GB DIMM will be in single channel mode.