"Duude, multi-gpu setups..especially on a single card; you're going to have issues because the amount of people who own those setups is much lower. a.k.a your a lower priority to nvidia or ati/amd. I don't mean to sound like an ass, but that's just the harsh reality of it."
Even disabling CFX (by adding the "Disable" flag to Catalyst AI in the driver profiles) does nothing to help Skyrim. Still chugs along with major hitches in Whitefall, for example. I can see waiting for a CFX CAP, after all CFX is a rather miniscule portion of the AMD customer, but there are/were major playability issues for me in every major A-list release this year on my Radeon, even running without CFX for those games, as I mentioned above. While the 480 is a single card only, I had zero issues with any newly released A-list game this year with it, and disabling Catalyst AI makes my 5970 into a single 5850 anyways, so that should make it a level playing field in terms of bugs. But it doesnt. Not even close.
I *want* to have the option of AMD for my next upgrade, but despite them making some amazing hardware, it ends up being hamstrung and crippled by shoddy drivers.