Does the card power up(Fans and shit)? IS the 2 6-pin connectors plugged into your card from your PSU?
If all of the above is done, try moving it to another PCIE 3.0 if you have another on ya board. Also try using your mobos graphics and going into the bios and making sure that the GPU is set to boot first
Also disk doesn't have latest drivers, download drivermax or go to amd website and download drivers manually for your R9 280x