performance wise the difference is negligible. power supply is a cost issue. seeing as gm204 is roughly pulling 200w per card with a stock limited overclock.... many could get by just fine with a quality 650w power supply powering sli gm204s and a single i7 overclocked. with the gk110 parts, you can definitely push over 300w per card at which point most would want a much higher wattage unit, 750w would likely work, but most would want a little more which would be 850w. so if this is a new build, you dont have a power supply above 750w, or your 750w supply is aging, you need to factor in the cost.