Generally the majority of people never touch the settings because simply there's no need to do so, only if you are more familiar let's persay with different graphical options and already knows what each one of graphical settings does and how it impacts ingame performance, then you could try tweaking the NVIDIA Control Panel settings by yourself to achieve the best gaming experience. Usually NVIDIA offers 3 different profile settings which are -
1 - Let 3D App Decide - This is the most used by lots of people who owns a NVIDIA card simply because in this setting, only those settings like VSYNC, TXAA, Texture Quality or anything similar that are changed in the "Application" only will take effect having no impact in your NVIDIA Control...