Since i also have NZXT HUE+ in use with my Skylake and Haswell builds (full specs with pics in my sig), i have few questions to ask:
1. Do you use NZXT CAM in Guest Mode or do you log in using your NZXT account?
When using guest mode, people have had issues with HUE+ remembering profiles, especially under Win 10.
2. When selecting a profile and customizing it to you likening, have you typed in the new profile name, so that NZXT CAM can save your custom profile?
I have saved lots of different profiles with proper names for easier switch when i get tired of one profile.
3. In the Settings, under General tab and in Boot Options section, have you ticked the boxes that state: "Auto-start CAM when Windows launches" and "Start CAM minimized"?
When i boot up my PC, all my LEDs (NZXT LED strips and AER RGB fans) shine in white color until my Win 7 boots NZXT CAM which starts in minimized mode. After my NZXT CAM starts working, it automatically loads the last saved profile i had prior to shutdown.
4. What is your NZXT CAM version?
I have version 3.3.0 in use while the latest is 3.5.10.