I think it may be game sensitive, but one of the most simple fixes I've seen is this. Right-click your game.exe and use compatibility mode for Windows XP. Before you run the game in question. Right-click your desktop and choose Screen Resolution. Now just leave that window open. Then run your game.
Another fix involves creating a batch file that you run that shuts down Windows Explorer and runs your game. Then restarts Explorer when you're done.
Create a new text file, open it.
Paste this into it -
@ECHO OFF
TASKKILL /F /IM explorer.exe
"C:\Program Files(x86)\Game Folder\Game.exe"
pause
START C:\Windows\explorer.exe
You will have to put the path to your game instead of "C:\Program Files(x86)\Game Folder\Game.exe"
Save the text...