Can be. We will show you. Not if you are careful.
MSI has a Windows based overclocking utility. Your motherboard manual tells you how to use it in Appendix B.
All of us recommend learning to use the BIOS.
This should be your first stop.
Core2 Overclocking Guide (generic guide based on an Asus motherboard)
http://www.tomshardware.co.uk/forum/259899-11-core-overclocking-guide
For another guide:
Shadow's Gigabyte motherboard OC guide:
http://www.tomshardware.co.uk/forum/page-245679_11_0.html
It's for an EP35-DS3L.
The MSI BIOS is different from both of those. Your overclock settings are in the Cell Menu. You need to set the FSB/DRAM Ratio so that your frequency is twice the FSB freq.
Take your CPU voltage off Auto.
Now you are ready to start the "increase FSB, test, increase CPU voltage if necessary and retest" cycle.
The rest of the voltage settings can be left on Auto until your learn more about what you are doing.
As long as you stay within recommended Intel limits, you are pretty safe from damage. Do not exceed 1.45 volts CPU core voltage and keep you load temps under 70 C. Except for random electronic failures, your system will likely become obsolete long before anything dies of overclocking effects.