Yes, the ASUS P6TD Deluxe supports SSD, and any SATA equipped MOBO will support an SSD. The 'problem' is the SATA2 limit of 300 MB/s (3 Gb/s), so ultra fast SSD's will need a SATA3 {edit} Card with x4 PCIe lanes, to utilize the faster SSD's (e.g. 550MB/s) out today.