We had a guy here a while ago...4 or 5 physical drives, with many many partitions.
He had 2 issues......He was literally running out of drive letters (He was up to 'Y') and wanted to know how to mount more drives/partitions.....This is somewhat doable...you can mount a partition without a drive letter. Messy, though.
And also wanted to resize a couple, because those partitions were running out of space...That was much more problematic. As in...no, you can't do this.
A few top level folders on each physical drive, and there would have been no problem.
1. Running out of drive letters is
NOT a problem you want to have, trust me.....and neither is mounting drives without a letter..
2. There are software tools that WILL allow you to resize partitions easily. And for routine data this is usually ok, but for critical data that you can not afford to lose, you should
ALWAYS have 1 (or 2, 3, 4) back-ups on other drives/machines/clouds
BEFORE attempting to resize the partitions it is on.
Again, trust me when I say that copying data from a backup to another drive is way, way easier & faster than trying to recover it from a crashed/wiped/dead drive !
3. Since getting my first computer in the early 80's, I have always used Folders as my primary method of keeping my data organized, easy to locate & access. But I also use partitions (on external drives) to separate different types of data, so that if I want/need to wipe one part while keeping the rest, I can do that and it also makes the wiping process much faster too