When it comes to fans and airflow (all fluid flow actually), there are two simple rules.
■Bigger is better
■Straighter is better
A 120mm fan is better than two 85mm fans despite having about the same surface area (14400 mm^2 vs 14450 mm^2). Airflow encounters more resistance at the hub and the ducts (edges). And the larger fan has more airflow further from these resistance-inducing components. A single large fan is also more energy efficient than two smaller fans, which in turn are more efficient than four (same is true for airplane engines, ship propellers, which is why the A340, 747, A380 are all losing out to newer twin engine aircraft). The main reason for having more than one fan is redundancy - so you'll still have airflow if a fan fails.
Also, in a one small vs one large fan scenario, the larger fan can push the same volume of air at a lower velocity, meaning it'll run quieter at a lower RPM.
Likewise, any any bends add resistance. This decreases airflow, increases noise and power consumption. So a simple fan sitting in the side of your case which moves air from one side to the other is best.
Length of tubing also adds resistance, but not significantly at the distances within a PC case.