I too have an issue w/ my e machine T3646 and a PNY (nVidia) GeForce 8600 GTS 512 OC 3GB DDR3 PCIe graphics card. I have AMD Sempron LE-1250 chipset, 2GB ram, and nVidia GeForce 6100 on board. I'm running win 7 Ult. 64/ x86 (2 SATA HD's 1 os ea.) I tested this card a week before I purchased it, and the first time it went in I had no issues at all...the card really pepped the machine up. I returned the card to owner ( he left it w/me) and reinstalled it a week later. Now I'm getting no signal at all, I had to plug my monitor back into the on board so I could get to the bios to switch the adv. conf. to PCIe slot, f 10'd it and switched back to the card (same monitor, have both DVI and VGA plugged in) and still nothing at all...the monitor switches from analog/digital until it times out and defaults to analog. The on board is still working even though the bios are set to PCIe slot. I did remove the boards battery and re-installed with no change. The card does not show up in device mgr. either....(?) is this a bus controller issue? any thoughts or suggestions welcomed.. Thank you.....