No technical issues at all. Except maybe extra time for searching and ordering required 2.5" drive mount accessories for 3.5" drive bay. Though laptop HDD usually have slower rotation (5400 and 5900 RPM instead of usual 7200 RPM in desktop HDD) so slower access time and even longer disk grinding during windows updates, installations, maintenance and other drive IO consuming tasks. If you can, buy SSD for system drive and use mentioned laptop drive for file archives. Your deskop will thank you.