Depends on the cooling power of your GPUs and the airflow you're providing. I'm assuming youre asking this because they're inside a case?
Unless you have EXTREMELY good airflow, you're probably going to have to remove the side panel and mount a boxfan of sorts directly up against the cards.
Monitor your temps closely when you start. Those cards are space heaters when it's just one... Them being cramped together on a board, in a case, running @ 100%..... gonna get TOASTY boyo. Make sure you set a GPU temp limit in your miner config so the miner stops mining on that gpu, when they get to a certain temp.