First, check your motherboard's memory QVL (qualified vendor's list) to see if your model and sizes of memory modules are on it. If they are not, it doesn't mean they will not work. It only means the motherboard maker didn't test that specific setup. Second, you are almost always better off going with a 2x instead of 4x set of memory modules on a non-X series Intel chipset. The reason for that is because of Intel's crappy memory controller on H and Z series motherboards. This is most crucial when overclocking which you do not mention.
Also just a note: the more information you give us about your system and question/problem, the better your answers will be.