The manual I'm looking at lists the DIMM socket labeling as DIMM_A1 (black, closest to CPU), DIMM_A2 (gold), DIMM_B1 (black), DIMM_B2 (gold, farthest from the CPU). Assuming this, I'd try the 2 4GB DIMMs in A1 and A2 and the 8GB in B2. This puts 8GB on each channel and the single DIMM on the farthest slot from the CPU. This sounds like it should give you the full 16GB in dual-channel.
Yes, it's more likely to work in matched pairs but if you've got the parts already you may as well try it and it will probably work.