I have a troubling problem. My boss has a computer running XP. It is 2.8 gHz 32 bit, 4g ram and about 40g hard drive space free. It was running so slow as to be unusable. She would click on an IE link and it would close the page then re-open it with dozens of pop-ups. Her home page and search engine were hijacked. I ran malwarebytes and got rid of 1300+ problems. I ran norton, spybot and ad-aware. Finally ran trend-micro housecall. It seemed to be clean. The problem is that it still runs incredibly slow. If you click on anything (web page or "my computer") it shows me the hourglass for about 5-10 min. I even see the flashlight sometimes. A 2.8 gHz machine shouldn't ever show those. I have the running processes down to a minimum. I cleaned out the start menu. In the task manager I see a bunch of cpu spikes but only briefly. The cpu and memory usage appear normal. When I run in safe mode it runs fine so that tells me it's not the hardware. I also ran process explorer and didn't see anything unusual. I have never run across anything like this. I am computer savvy and have dealt with many virus filled machines. This is by far the worst I have ever encountered. I spent over 8 hrs. trying to fix it. 95% of that was waiting for it to respond to mouse clicks. Any help or ideas are welcome as I don't know what to look for at this point.