Question Reason for PC crash after opening a program?

[nullchecker]

Hi,
i have deleted a mp3 file in a folder, which was used by my audio software at that time and the pc crashed immediatly.
Since then my PC crashes after an unpredictable time.
It crashed again and again after i´ve tried to open the windows explorer and different other software.
Sometimes at first action after reboot (opening windows explorer), sometimes 2-5 minutes later after opening different software. Even watching a 10 minute Tutorial movie offline.

I changed the RAM´s slots and thought problem was solved, cause i could work for maybe 10-20 minutes in a video editing software after that.
But then it crashed again ana again as soon i wanted to open the software again.

Any ideas what the reason could be? Software, Hardware?
How can i check the reason and fix this?

My System:
OS: Win 8.1 pro
Motherboard: MSI Z97 PC Mate
CPU: Intel Core i7 4790 - 3.6 Ghz
GC: Sapphire R9 280X OC - 3GB
RAM: Kingston HyperX T2 Predator 16 GB
HHDs: SSD Samsung 840 EVO 250GB, WD 1 B Blue 7200 SATA 3

Thanks in advance

 

[CountMike]

Run "sfc /sannow" from Admin command prompt.

 

[me 1]

Does it do the same in safe mode?
Look for clues in event viewer.
Also, did you personalized some windows sound setting, was that file used as as a windows startup sound by any chance?

 

[nullchecker]

Hey guys, thanks for your quick replies.
I´m new here so I didn´t expect that.

After asking my question here, I went to the store yesterday to looking for some new RAM´s, cause somehow i thought maybe that´s the reason.

I got a tip to check my RAM´s writing mdsched in the command prompt.
So i did.
I went first with the basic setting and it found no problems.
I wanted to be sure and I ran it a second time with the advanced setting.
Maaan, it took nearly 10 hours.

I worked a few hours last night, to check if everything is ok and it seems fine again. Hopefully.
So thanks again for your help.

Have a nice day.