theyeti87 :
Might as well buy a 1070 or 1080 if you're willling to buy 2 GPUs. Get a much better single GPU.
You do realize he is asking about a $110 GPU, 2 of which would be about $220, vs $400 for a 1070.
OP The RX 460 will run in crossfire, however Spending $220 on 2 of them at 2gb is a waste. For that amount you can spend a little more and get an RX 480 with 8gb (or about the same and get an RX 480 4gb if you can find one) and run any game well. The RX 460's will be limited by 2gb of memory and that not every game supports crossfire.
IMO Crossfire and SLI should be limited to those who want to do an extreme build with high end cards that want to go faster. With lower end cards its just not worth it.