As far as I know, this program only uses CPU and does not use GPU, therefore any GPU works for it.
Since I5-9600K has an iGPU you would not need to purchase a GPU separately. Instead with the Ryxen you need to buy a GPU.
On the other hand, the I5 does not include a cooler and the Ryzen does.
To get all the power out of the i5-9600k you need a mobo Z390 to enable OC. At Ryzen 5 2600 you get a cheaper B450.
I5-9600K is much more powerful than Ryzen 5 2600 (another thing would be Ryzen 5 3600).
Do your sums and choose.