Yes. On the
mortar (-link to specification) the lowest pci-e 16x (pcie_4) slot is disabled when the m2 sata drive is installed but the topmost slot is available for 1 16x 3.0 gpu in other words you wouldn't be able to xFire 2 radeon gpu's with the m2 sata drive installed. It supports the nvme 3x4 drive without any restrictions.
The
steel legend (link to specification) disables one Sata port when the m2 sata drive is installed so you only have 3 of 4 sata ports available for optical drives/ssds/hdds. So you could have 2 optical drives and one more ssd or hdd.
The nvme 3x4 has no restrictions and also since the second pci-e slot is not restricted by the sata m2 drive you could run 2 radeons in xFire mode while the m2 sata drive is installed, assuming your power supply unit is of sufficient capacity to support 2 power hungry radeons.
One thing to note if you plan to xFire 2 radeons, is sometimes some chassis that aren't the largest, means that the lowest pci-e slot is blocked for a gpu by the power supply being on the floor of the case, or if the psu is at the top, there may still not be enough clearance off the floor of the chassis, to install the second gpu. Cases vary in dimensions. These look like mATX boards so there would be enough clearance in most mid-atx cases but there might be clearance problems with specifically microATX cases for dual cards.
I don't think you'll have any system bottlenecks using the nvme 3x4 as your primary boot drive with the windows page file on it, no data transfer bottleneck, that would only be a bottleneck if you were using an hdd as a system drive, not an ssd.
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