Those of us on Windows 7 need to do a few things to get this to work correctly. I don't know if this affects just the 64-bit version (which is what I run on), but I had trouble getting this to run.
If you are attempting to run the game and even though it appears as if it's loading but eventually it doesn't, then you need to create an icon on your desktop. Right click on it and set the compatibility mode to by Vista SP1 or SP2. This fixed the problem for me. Now, if I could just get it to load faster. Currently, it takes about 2 to 3 minutes to load. Once it's loaded, the game runs great and I'm only 15 minutes into the game but I'm already enthralled by the story and can't wait to see what happens. Oh, and it looks gorgeous.