While it will work, I cannot say that you will be able to use it as your boot device (and I suspect not -- but not for any other reason than the board is older and the last bios I see is from 2014 and may not support a PCIe boot device??).
What adapter are you using and which bios revision are you on to assist those who may have tried this already?
I'll ask some of the other users to drop by and opine on this further.