https://dlcdnets.asus.com/pub/ASUS/...71_PRIME_Z370-A_UM_WEB.pdf?model=PRIME Z370-A
"Intel® Z370 Chipset with RAID 0, 1, 5, 10 and Intel Rapid Storage
Technology support*
- 1 x M.2 Socket 3 with M Key, type 2242/2260/2280 storage devices
support (both SATA & PCIE mode)**
- 1 x M.2 Socket 3 with M Key, type 2242/2260/2280 storage devices
support (PCIE mode only)***
- 6 x SATA 6.0 Gb/s ports (gray)
- Ready for Intel ® Optane Memory
* Supports PCIE RAID configurations via onboard M.2 storages.
** The M.2_1 socket shares SATA_1 port when use M.2 SATA mode device. Adjust
BIOS settings to use a SATA device.
*** The M.2_2 socket shares SATA_56 ports when use M.2 PCIE mode device in X4
mode. Adjust BIOS settings to use M.2 PCIE devices in X4 mode."
depend on where you put the nvme. should have at least 4 working sata