"If you are a glutton for punishment, try Ubuntu 64-bit "
Only if your DAW process will consume around 2Gb or more when running, the vast majority will get by just fine with 32bit, and it's not THAT hard to get your Alsa drivers working(not sure about 64bit drivers...):
Install through Synaptic: libalsa(?) alsa-mixer alsa-mixer-gui jackd qjackctl alsa-utils
Go here and get your Alsa driver, and follow the instructions to compile and install for your specific soundcard:
http://www.alsa-project.org/main/index.php/Main_Page
I'd also recommend going the extra mile and installing the latest dev version of wine:
www.winehq.org
Then search the internet for the latest wineasio.dll.so file(compiling it requires obtaining the ASIO sdk from Steinberg, major PITA), then place it on your desktop and paste the following command into the terminal:
cd ~/Desktop; sudo cp wineasio.dll.so /usr/lib/wine; regsvr32 wineasio.dll
Now you have working Asio drivers for wine applications... Too easy, right?
You can now download reaper from www.reaper.fm, and install your plugins as normal. If any of them don't work properly, try logging in as root to do it.
PS: I'll do a Tom's article on how to do Linux audio for $600
😀